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Epigenetic repression of miR-375 is the dominant mechanism for constitutive activation of the PDPK1/RPS6KA3 signalling axis in multiple myeloma.
Tatekawa S, Chinen Y, Ri M, Narita T, Shimura Y, Matsumura-Kimoto Y, Tsukamoto T, Kobayashi T, Kawata E, Uoshima N, Taki T, Taniwaki M, Handa H, Iida S, Kuroda J. Tatekawa S, et al. Br J Haematol. 2017 Aug;178(4):534-546. doi: 10.1111/bjh.14707. Epub 2017 Apr 25. Br J Haematol. 2017. PMID: 28439875 Free article.
However, we recently showed that the serine/threonine kinase PDPK1 and its substrate RPS6KA3 (also termed RSK2) are universally active in MM, and play pivotal roles in myeloma pathophysiology. ...Introduction of miR-375 reduced PDPK1 expression in human myelo …
However, we recently showed that the serine/threonine kinase PDPK1 and its substrate RPS6KA3 (also termed RSK2) are universall …
Expression pattern of the Rsk2, Rsk4 and Pdk1 genes during murine embryogenesis.
Kohn M, Hameister H, Vogel M, Kehrer-Sawatzki H. Kohn M, et al. Gene Expr Patterns. 2003 May;3(2):173-7. doi: 10.1016/s1567-133x(03)00004-8. Gene Expr Patterns. 2003. PMID: 12711546
The ribosomal S6 kinase family members RSK2 (RPS6KA3) and RSK4 (RPS6KA6) belong to the group of X chromosomal genes, in which defects cause unspecific mental retardation (MRX) in humans. ...
The ribosomal S6 kinase family members RSK2 (RPS6KA3) and RSK4 (RPS6KA6) belong to the group of X chromosomal genes, in which defects …